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How effective is inactivated vaccine in Omicron？ What is the strategy of universal vaccine？ China team ＂Nature＂ issued a document.

Omicron is the most serious mutation so far. There are more than 30 mutations in spike protein, 15 of which occur in receptor binding domain (RBD). This COVID-19 mutant poses new challenges to scientific research and epidemic prevention decision-making. A recent study published in Nature, a top academic journal, pointed out that a key question for China is whether the inactivated vaccine that has been inoculated on a large scale also has a severe protective effect on Omicron mutant.　

On January 28th, Nature published a study jointly completed by researchers from the Institute of Biophysics of Chinese Academy of Sciences, the Institute of Medical Experimental Animals of China Academy of Medical Sciences, the Institute of Microbiology and Epidemiology of the Academy of Military Medicine of the Academy of Military Sciences, China Institute of Food and Drug Control (NIFDC), Beijing Kexing Biological Products Co., Ltd., etc. The research team systematically analyzed the titer of neutralizing antibodies in the serum of volunteers vaccinated with CoronaVac and the antibody spectrum of memory B lymphocytes.　

The research was led by researcher Wang Xiangxi from Institute of Biophysics of Chinese Academy of Sciences and Key Laboratory of Infection and Immunity of Chinese Academy of Sciences. Other correspondents included researcher Qin Chengfeng from Institute of Microbiology and Epidemiology of Academy of Military Medicine of Chinese Academy of Military Sciences, Wang Youchun, chief expert of vaccine testing of China Food and Drug Testing Institute, and Qin Chuan, director of Institute of Medical Experimental Animals of China Academy of Medical Sciences.　

It is mentioned in the paper that although the currently approved COVID-19 vaccine continues to be effective against serious diseases and deaths caused by Delta mutants, the third dose of vaccine or even the development of new vaccine is needed due to the decreased immunity and large-scale breakthrough infection caused by virus mutation.

Previously, on December 8, 2021, Pfizer announced that a preliminary laboratory study showed that three doses of Pfizer /Biontech mRNA COVID-19 vaccine BNT162b2 could neutralize the mutant strain in Omicron, Covid-19. Compared with two doses of vaccine, inoculation of three doses of the vaccine increased the titer of neutralizing antibody by 25 times.

The research team believes that these preliminary data about Omicron neutralization sensitivity need further independent verification, and the clinical effects of natural immunity and vaccine-induced immunity in preventing infection and serious diseases also need urgent investigation. As far as China is concerned, inactivated vaccine has been inoculated on a large scale up to now. Does this also have a serious protective effect on Omicron mutant? What is the necessity of three doses of vaccination?

In this study, Wang Xiangxi et al. collected the sera of 60 volunteers who had been inoculated with inactivated vaccine twice (in the procedure of October and January) and 60 volunteers who had been inoculated with inactivated vaccine three times (in the procedure of October, January and July), and evaluated their neutralization titer against the original strain and Omicron mutant by COVID-19 live virus neutralization test. None of these volunteers were infected with Covid-19 before the study, and blood samples collected four weeks after the last vaccination were used in the study.

Evolution and neutralization characteristics of Omicron mutant.

The data showed that the geometric mean median maximum neutralization titer (GMT NT50) of the volunteers inoculated with three doses of inactivated COVID-19 vaccine against wild-type (WT) virus, Delta and Omicron mutant were 253.9, 77.8 and 15.4, respectively. Compared with the wild-type virus, the semi-maximum neutralization titer of Delta and Omicron decreased by 3.3 times and 16.5 times respectively. Three of the 60 volunteers had an NT50 titer of less than 8 for Omicron. In other words, the seroconversion rate of neutralizing antibody against Omicron in volunteers vaccinated with three doses of inactivated COVID-19 vaccine was 95%.

However, they mentioned in their research that what deserves more attention at present is the effectiveness of the two-dose vaccination program for Omicron infection. In the two-dose inoculation group, compared with the wild-type (WT) virus, the NT50 titer of Delta was 6.6, which was 5.1 times lower. Notably, none of the 60 volunteers had a serum sample with an NT50 titer greater than 8 for Omicron.

These results showed that the neutralizing ability of COVID-19 mutant strain was poor after inoculation with two doses of inactivated vaccine, and the neutralizing antibody titer in vivo could be improved by inoculation with the third dose of inactivated vaccine. However, the titer of neutralizing antibody against Omicron mutant was still low. The research team believes that their data is consistent with previous observations, that is, three doses of inactivated vaccine inoculation can enhance the neutralization breadth of SARS-CoV-2 mutant.

Strengthen the characteristics of broad-spectrum neutralizing antibodies in needle volunteers.

It is worth noting that after the existing vaccination, the level of neutralizing antibody in serum is not enough to fully curb breakthrough infection, so why can it effectively provide severe protection?

The research team isolated immunoglobulin (IgG+) memory B cells from peripheral blood mononuclear cells (PBMCs) of four three-dose vaccinators, obtained the sequences of antibody heavy chain and light chain variable regions and expressed 323 strains of antibodies in vitro. They found that 163 antibodies recognized virus RBD, 100 antibodies recognized NTD and 51 antibodies recognized S2. The test results also showed that almost all antibodies that bind to RBD can bind to wild-type strains, among which 127 antibodies have neutralizing activity against wild-type strains of real and pseudoviruses, and they chose these antibodies for further study.

Among these 127 strains of antibodies, more than 93% showed extensive binding activity to most of the mutants of concern and interest. It is worth noting that 85% of these antibodies cross-react with Omicron RBD.

In contrast, about 80% of NTD-binding antibodies lost their cross-reaction with Omicron. In addition, due to the great diversity of NTD, the cross-reaction of NTD antibody to the other four variants of concern is relatively poor.

Their research also found that among the antibodies binding to RBD region, 31 strains can effectively neutralize wild-type pseudoviruses and true viruses and all concerned variants, and the semi-inhibitory concentration IC50 is between 0.002 and 0.800μg/ml. Among them, 30 strains of antibodies can directly block the binding between RBD and ACE2.

Among the 31 strains of broad-spectrum potent antibodies isolated in this study, 13 strains have IC50 less than 0.02ug/ml to Omicron, which is 10-40 times as high as that of VIR-7831 from GSK/Vir and DXP-604 which is still in the clinical trial stage in China.

The structural basis of extensive and effective neutralization of representative antibodies.

The research team also selected four antibodies for further structural biological analysis. Among them, XGV347 (class II antibody) and XGV289 (class IV antibody) have strong neutralizing activity against all concerned mutants, including Omicron.

They also identified the interaction between these antibodies and Omicron spike protein, and identified a mutation G446S of spike protein, which is more resistant to a class of antibodies that bind to the receptor binding domain and is a key escape site.

Structural comparison shows that XGv347 is similar to a neutralizing antibody (A23-58.1) which is effective against several Covid-19 mutants, and is similar to the epitope (antibody binding site) targeted by another neutralizing antibody (S2K146). It is worth noting that S2K146 is effective against other strains of coronavirus B (i.e., subgenus sarbecovirus, a group of virus strains to which Covid-19 belongs).

Further experiments in this study also show that the representative broad-spectrum neutralizing antibody therapy has a high protective effect on the infection of beta mutant and Omicron mutant in mice.

Protective effect of neutralizing antibody therapy on infection of beta mutant and Omicron mutant in mice.

The research team believes that this study proves that the three-dose vaccination program is reasonable under the current pandemic. At the same time, antibodies that identify and identify epitopes in the same region can be classified, and different types of antibodies can form cocktail therapy, which can be used to prevent and treat current epidemic strains and new strains that may appear in the future, or help to develop a general vaccine strategy for branch B of coronavirus B.

Original link: https://www.nature.com/articles/s41586-022-04466-x

Over 15,000 construction sites in Guangdong have resumed work, and the resumption rate of key projects has reached 93%.

　　According to the Provincial Department of Housing and Urban-Rural Development, by deepening the reform of the examination and approval system for engineering construction projects, enterprises in the housing and construction sector in the province have resumed their work and production.

　　As of March 23, 15,746 construction sites in the province have resumed work, with a resumption rate of 85.4%. Among them, 4,184 provincial and municipal key housing projects, including epidemic prevention and control, urban operation, and basic people’s livelihood, have resumed work, with a resumption rate of 93% for key projects.

　　Multi-measures to improve the efficiency of examination and approval of engineering construction projects

　　Previously, many construction enterprises in the province were greatly affected by the epidemic. On the basis of Guangdong’s "Several Policies and Measures for Supporting Enterprises to Resume Work and Production in Response to Pneumonia Infected in novel coronavirus", the Provincial Department of Housing and Urban-Rural Development issued 10 measures to benefit enterprises, provide good service for returning workers, ensure the supply of protective materials and building materials, and strengthen financial "escort" to bring a "timely rain" to construction enterprises.

　　At the same time, the office of the leading group for the reform of the examination and approval system of provincial engineering construction projects requires that all localities help enterprises to resume work and production through a number of reform measures. On the one hand, we will speed up the improvement of the examination and approval management system for construction projects, do a good job in the interconnection of various platforms, give full play to the advantages of online examination and approval of the examination and approval system for construction projects, and implement "online" and "fingertip" approval for construction projects.

　　At the same time, we will implement "appointment office" and encourage "nearby office", and make "appointment office" through online, telephone and email for some examination and approval items of engineering construction projects that really need to be handled at the physical hall site, and encourage qualified areas to implement "nearby office".

　　In particular, it is also required to vigorously implement the approval notification commitment system. For matters subject to the notification commitment system for examination and approval, the deadline for submission of materials agreed in the undertaking can be made up in principle after the end of the epidemic.

　　In addition, for special projects of epidemic prevention and control, we should do a good job in service guarantee, such as special construction projects such as public health service houses and supporting facilities needed for epidemic prevention, and implement special services and active services, and establish a one-stop green channel for parallel approval of the whole chain and approval within a limited time.

　　Simplify the examination and approval process to ensure the start of major projects

　　The reform of examination and approval of engineering construction projects requires that the whole process of examination and approval should be simplified, the examination and approval process should be optimized, the bill of materials should be reduced, and finally the time should be shortened. This time coincides with the impact of the epidemic, and such streamlining is even more urgent. Many cities in the province have put forward innovative measures.

　　In Zhuhai, the land urgently needed for epidemic prevention and control can be used first according to the plan. Among them, there are special requirements for site selection, and it is really necessary to occupy permanent basic farmland and ecological protection red line, which is regarded as a major project to allow occupation, and outdoor requirements such as permanent basic farmland occupation and field reconnaissance are temporarily cancelled; If permanent land is needed, the relevant land use and planning procedures shall be completed according to the actual land use within 6 months after the outbreak is lifted.

　　Maoming City has speeded up the emergency of epidemic prevention and control and the urgent need for approval of industrial resumption. For those involving multi-department approval, it only takes one day from receipt to issuance of construction permits for large projects such as Junmingcheng Project, Dafatang Village Demolition and Resettlement Housing Construction Project, Blu-ray Yongjin Peninsula Project and Maoming Baolitianhuan Project.

　　Shaoguan City implements the "notification commitment system" for the construction projects affected by the epidemic, and arranges special personnel to intervene in the project plan review in advance. Jiangmen City supports epidemic prevention and control construction projects to use land first, fully guarantees the land use index of epidemic prevention and control projects, and implements the "tolerance and acceptance" mechanism for approval materials.

　　During the epidemic, several cities have also established and improved relevant management systems for online examination and approval of construction projects, and launched online examination and approval offices to avoid crowd gathering and improve examination and approval efficiency.

　　Foshan City relies on the integrated platform of examination and approval management of engineering construction projects, and all projects are declared, approved and technically reviewed online in the whole process. The construction unit only needs to fill in "a form" and submit "a set of materials". From January 26th to March 12th, a total of 249 engineering construction projects were declared paperless online.

　　In Huizhou, due to the epidemic situation and traffic control, the staff of several construction projects could not return to their posts on time, which seriously affected the examination and approval. As a result, the approval is organized in a "cloud office" and way. On February 12th, the planning and construction headquarters of Baihua Town New Materials Industrial Park in Huidong County held a remote video conference to convene technical teams from Beijing, Guangzhou and Shenzhen to study the planning of the industrial park and promote the karst and geological investigation and seismic safety evaluation of the industrial park.

　　Optimizing examination and approval service to facilitate enterprises to handle it.

　　In addition to various reform measures, several cities also optimized approval services during the epidemic. At present, all localities are constantly improving the comprehensive service window for the examination and approval of engineering construction projects, doing a good job of online and offline integration with the examination and approval management system of urban engineering construction projects, basically realizing "one network to run", establishing and improving the green examination and approval channel, and constantly promoting innovative services such as agency.

　　33 agents of Foshan configuration project provide services for 95 key projects; The two-level administrative service centers in Zhongshan Town provide "non-stop service on weekends" and provide free agency services for the whole process of approval and construction application for key enterprise projects and construction projects. Chao ‘an District of Chaozhou City has also set up an entrusted service area, and sent special personnel to provide pre-service for projects involving the production of materials needed for epidemic prevention and control. In addition, Zhuhai, Shaoguan and other cities organized party member cadres to dock key construction projects, deliver policies, services and coordinate protective materials.

　　Digital Guangdong Company is responsible for the development, construction and operation and maintenance of provincial and most urban engineering construction project approval management systems, and provides "7×24 hours" safety operation and maintenance, system operation answering and business data reporting during the epidemic period to ensure the normal operation of the engineering construction project approval management system.

　　In addition, various localities have also adopted the commitment system to simplify the procedures for enterprises to resume work and production as much as possible. At present, the construction enterprises in all parts of the province have basically realized the "settlement of the application for resumption of work", that is, the same day of application, the same day of handling, the same day of filing, and the same day of resumption of work, and the construction enterprises that have put in place epidemic prevention measures and actively fulfilled their obligations to resume work are given credit points and other rewards. For example, if Shenzhen implements "return to work first, then check", the enterprise will make good preparations for epidemic prevention, and after meeting the conditions for returning to work and submitting the filing form and commitment letter, it will organize its own return to work and resume production, and the relevant government departments will visit the site to check the implementation of epidemic prevention measures in due course. Zhuhai provides 24-hour policy consultation and answering services, helping to handle more than 2,000 requests for enterprises to resume work and production. Meizhou City has introduced relevant measures to warm up enterprises, which can help enterprises solve practical problems from the aspects of delaying the payment of special maintenance funds for residential buildings, relaxing the retention ratio of pre-sale supervision funds and increasing the number of withdrawals.

Going to the Grass-roots in the Spring Festival to Ensure Spring Festival travel rush’s ＂Warmth＂ with meticulous ＂heart＂ —— A glimpse of Spring Festival travel rush Railway in 2023

　　Xinhua News Agency, Beijing, January 14th Title: Ensuring Spring Festival travel rush’s "warmth" with meticulous "heart" — — The first-line experience of Spring Festival travel rush railway in 2023

　　Xinhua News Agency reporters Chen Xu and Ding Jing

　　With the opening of the first Spring Festival travel rush after the epidemic prevention and control entered a new stage, the railway passenger flow rose rapidly. How does the railway department ensure a safe Spring Festival travel rush, an orderly Spring Festival travel rush and a warm Spring Festival travel rush? With questions, the reporter visited important railway stations and railway services in Beijing.

　　Emergency passenger access and medical services, Spring Festival travel rush’s "homecoming" is very warm-hearted

　　Full of anxious to return wanderers, heading for the hometown looking forward to reunion. Since entering Spring Festival travel rush on January 7th, the passenger flow of major railway stations in Beijing has been rising continuously. According to the data of the Ministry of Transport, it is estimated that the total number of passengers in Spring Festival travel rush this year will be about 2.095 billion, returning to 70.3% in the same period in 2019.

　　During the period of Spring Festival travel rush, passengers lined up in the waiting hall of Beijing South Railway Station to check in, which was orderly. (Photo by Xinhua News Agency reporter Chen Xu)

　　"Thanks to the adequate preparation in the early stage, the operation of Beijing South Railway Station is generally stable and orderly." Dong Fang, secretary of the Party branch of Beijing South Railway Station Passenger Transport Workshop of China Railway Beijing Bureau Group Co., Ltd., said that the station analyzes the passenger flow demand in real time, grasps the pre-sale and standby situation of tickets for key hot directions in time, and puts in capacity step by step.

　　At the entrance of Beijing South Railway Station, a passenger found the station staff: "There are still 15 minutes to drive, please help me." Under the guidance of the staff, the passenger got on the bus smoothly through the "urgent passenger" channel.

　　On the platform, Han Chang, a staff member of Runqiu Service Group, is pushing disabled passengers onto the bus. "To serve passengers, we have no destination." Han Chang said that every "Spring Festival traveler" has devoted himself to his work and used more meticulous work to ensure the warmth and peace of mind of passengers during their journey.

　　On the platform of Beijing South Railway Station, Han Chang (first from the right), a staff member of Runqiu Service Group, is helping key passengers. (Photo by Xinhua News Agency reporter Chen Xu)

　　It is reported that during the Spring Festival travel rush this year, Beijing South Railway Station was not completely closed at night, and a rest area was designated for passengers who needed to wait for a rest; Open a medical service point in the waiting room in conjunction with Beijing You ‘an Hospital to provide help to passengers in need; Set up a "small color bar" for the navigation of bus routes to major railway stations in Beijing, and provide portable call bells for key passengers … …

　　"Warm service is reassuring." Mr. Song, who brought his children to see a doctor in Beijing from Weifang, Shandong Province, said that the high-speed rail lines are getting denser and denser, and he can travel to and from Beijing on the same day, hoping that the children in the Year of the Rabbit will recover and have a better life.

　　First "physical examination" and then online, high-speed rail "doctor" to protect train safety

　　After three years of epidemic, the railway passenger flow plummeted. Many vehicles "lie prone" on the road in the depot. How are their maintenance work done? Can you successfully pass the "big exam" in Spring Festival travel rush? The reporter went to the largest EMU maintenance base in Beijing, Tianjin and Hebei — — Beijing EMU of China Railway Beijing Bureau Group Co., Ltd.

　　As the only EMU in Beijing, Beijing EMU is equipped with 228 EMUs, which are responsible for the maintenance and debugging of EMUs on Beijing-Shanghai, Beijing-Guangzhou, Beijing-Zhangjia and Beijing-Harbin lines.

　　During the period of Spring Festival travel rush, two Harmony cars were being overhauled in the maintenance workshop of Beijing South motor vehicle application of Beijing EMU. (Photo by Xinhua News Agency reporter Chen Xu)

　　"Others have holidays, and the busier we get, the colder and busier the weather." Wei Wei, deputy section chief of Beijing EMU Depot, led the reporter to the maintenance workshop. In order to ensure the EMU to go online in Spring Festival travel rush in the best condition, the Depot began preparations early.

　　At eight o’clock in the morning, technician Wan Qixin packed his equipment and began to carry out maintenance. In the eyes of high-speed rail "doctors", "seeing a doctor" for the train is a "conscience work", and every link is indispensable. To be foolproof, we must be in awe.

　　Wan Qixin’s team is going to inspect the hollow shaft of the train today, which has a great influence on the safe operation of the EMU. In the past, when overhauling, the old master used to beat with a small hammer and listen to the sound to judge the injury. Now it is more reliable and efficient to use ultrasonic flaw detectors.

　　Technician Wan Qixin (first from left) put the flaw detector weighing more than 40 kilograms into the hollow shaft. (Photo by Xinhua News Agency reporter Chen Xu)

　　"After the start of Spring Festival travel rush, the 12 maintenance lanes of the whole station kept ‘ Overturn ’ 。” Wan Qixin said that with the launch of various models such as Harmony, Fuxing and Fuxing intelligent EMUs, the challenge of maintenance work is even greater. Technicians should constantly learn and enhance their skills to ensure the health of vehicles and the safety of Spring Festival travel rush.

　　Healthy New Year’s Day Reliving Winter Olympics "Ice and Snow Tour" of Beijing-Zhangjiakou High-speed Railway is very popular.

　　With the opening of Spring Festival travel rush, the Beijing-Zhangjia high-speed railway ushered in the first skiing craze after the end of the Beijing Winter Olympics.

　　At Qinghe station, many passengers are waiting to take the D6715 train of Beijing-Zhangjia high-speed railway and go to Chongli to experience the fun of ice and snow. Wang Xiaoyong, the stationmaster of Qinghe Station of China Railway Beijing Bureau Group Co., Ltd., said that it is estimated that the number of passengers sent in a single day during Spring Festival travel rush will be between 20,000 and 25,000, which will reach the highest level since the station was opened.

　　Driven by the Beijing Winter Olympics, more and more people in Chinese understand and like ice and snow sports.

　　On the Beijing-Zhangjia high-speed train D6715, the conductor is checking the fixation of ski equipment. (Photo courtesy of the interviewee)

　　"Since the opening of Chongli Station for one year, the passenger flow has gradually increased. During the New Year’s Day holiday this year, the number of snowboards transported in a single trip has reached nearly 100. In time for Saturday and Sunday, the trains will be reconnected." Wang Yali, conductor of Beijing-Zhangjia high-speed railway in Beijing Passenger Transport Section, said that in order to facilitate passengers carrying skis, Qinghe Station added a ski consignment point in the waiting hall to facilitate passengers to check in.

　　Mr. Pang, a 25-year-old working in Shanghai, flew to Beijing on weekends. After changing from Daxing Airport to Qinghe Station, he transferred to Beijing-Zhangjia high-speed train to Chongli. "The whole process is smooth and the traffic is very efficient. We can go back to work on Monday after skating on the weekend." Mr. Pang said.

　　In the rising passenger flow, it is the warmth of quietly returning. In 2023, Spring Festival travel rush brought back people’s long-lost fireworks and revived vitality and hope. The new year will be even better.　

Rulu’s ex-boyfriend, an original, once participated in treading on thin ice. Will he have a chance to participate in Actor 3？

Rulu and Carina Lau starred in "The Origin of Love" with constant bad reviews. Because of Rulu’s previous role filter, the role of Gu Manzhen has no sense of substitution. In and out of Rulu’s plays, people feel "strong", and even her feelings are affected.

Rulu has been famous for many years, but there is little news about her feelings. At present, the only boyfriend she admits is Ye Zuxin.

Ye Zuxin and Rulu met in 2003, when they were both young actors. Because of their professional relationship, they had more contact opportunities.

2011 was a lucky year for both of them. Ye Zuxin gained attention with the role of "Old Ten" in treading on thin ice, and his career developed rapidly afterwards. Jiang Xin went out of the circle with the help of the role of "Hua Fei" in Empresses in the Palace.

The official announcement of their love affair was on July 13th, 2013, when Nicky Wu, Liu Shishi, Yang Mi and Hawick Lau made public happy events.

In fact, this love affair has a long history. On the Double Eleven in 2013, Rulu made a deep confession in Weibo. In the attached photo, Ye Zuxin’s shadow can be seen in the sunglasses.

Huafei and Tenth Master got together like this. Jiang Xin was one year older than Ye Zuxin, and this relationship was naturally labeled as "love". Like other star couples, the two have joined hands in various festivals and spilled a lot of dog food.

Rulu’s career has developed quite well since "Hua Fei", but Ye Zuxin’s role has not received much attention since "treading on thin ice", although he has a play appointment.

Rulu and Ye Zuxin formally broke up on July 12th, 2015, because the relationship of "women are strong and men are weak" in the entertainment circle is doomed to have no good result.

Many people have speculated that the two broke up because of the career gap, but Rulu thought that he was a very good predecessor and a person who could still be friends after breaking up. Even when Ye Zuxin was questioned by various kinds, Rulu came out to speak for him, and he was treated like this by his predecessor after breaking up, which shows that Ye Zuxin people are really quite good.

After the breakup, Ye Zuxin’s career was tepid, but she was suspected of making progress in love.

Ye Zuxin and Karlina were photographed visiting each other, and even Ye Zuxin was photographed accompanying Karlina to the hospital for examination, but neither of them responded.

In 2022, Ye Zuxin played Zhang Maoze in Qing Ping Le, a well-versed, sophisticated chamberlain. Song Renzong’s confidant, Cao Empress’s confidant, Liang Huaiji’s mentor, and Zhang Maoze in multiple identities play an important role in promoting the plot.

Unlike the chamberlain in other TV dramas, Zhang Maoze, played by Ye Zuxin, does not have albert nobbs’s voice, but instead sees his temperament, which makes people completely forget the "Ten Masters" in treading on thin ice. From this perspective, he is successful.

A few days ago, Ye Zuxin, 36, was the official guest speaker of "I am an Actor 3". He doesn’t have the high popularity of young Aidou, and his sense of variety is not as high as that of Xiao Shenyang and Pan Binlong. Among the 33 actors, his advantage is not a star.

In "Actor in Place 2", many actors got new script invitations with the help of the program. The overall lineup of "I am an Actor 3" is not bad either, but "Actor in Place 2" slowly fell into the street after the word of mouth, so how many opportunities Ye Zuxin can have in the program depends on his performance in the program.

Editor in charge:

Jietu Automobile officially announced that it has reached a cooperation with CCF to build a new milestone in cheetah protection.

Jietu Automobile officially announced that it has reached cooperation with CCF.

While pushing forward the globalization strategy, Jietu Automobile closely focuses on the concept of "travel+",which not only focuses on economic growth, but also deeply cares about the natural and human environment. The cooperation with Discovery Channel led Jetway into Namibia, confronted the cheetah’s survival crisis, and inspired its determination to participate in conservation actions. Jietu Auto officially announced that it has reached a cooperation with CCF!

In April this year, Jetway established contact with the Cheetah Conservation Foundation (CCF), which was founded by Dr. Laurie Marker in Namibia in 1990 and is a pioneer in the global cheetah conservation research. After months of communication, the two sides decided to work together to promote cheetah protection.

On September 20, 2024, Jetway Auto officially announced that it had formed a strategic partnership with CCF in the new product launch event in South Africa, and promised to work together to improve the living environment of cheetahs by adopting cheetahs and donating official vehicles. In addition, Jetway will cooperate with Discovery Discovery Channel to shoot a documentary about cheetah protection, and launch a global "Protecting Cheetah" campaign to attract more people’s attention and participate in the protection work.

Dr Laurie Marker emphasized that cheetah protection needs perseverance, and the long-term spirit displayed by Jetway coincides with CCF. She expressed gratitude for Jietu’s support and looked forward to deepening cooperation between the two sides and encouraging more people to join the global protection of endangered cheetahs.

Ke Chuandeng, deputy manager of Jietu brand, spoke highly of this cooperation and thought it was both an honor and full of expectation to participate in such a cause. Jietu hopes to raise public awareness of wildlife protection through its own actions and encourage more social forces to join the public welfare ranks of cheetah protection.

Jietu Automobile has never stopped on the road of public welfare. Whether it is the "Way to Hope" plan for left-behind children in China or various public welfare activities carried out internationally according to local characteristics, it embodies its corporate philosophy of "Travel is public welfare". The cooperation with CCF marks the first time that Jietu has incorporated animal protection into public welfare action, which has deepened the connotation of the "Travel+"strategy and marked the beginning of its public welfare action. Jietu Auto officially announced that it has reached a cooperation with CCF!

In the future, Jetway will continue to promote "travel is public welfare", and find meaning, create positive influence and share beauty with users in the journey of travel and public welfare.

Extreme Fox Alfa T5 intelligent four-wheel drive, the driving choice for extreme fox cars to conquer all kinds of road conditions.

Driven by the current wave of intelligence, cars are no longer just a means of transportation, but have become an intelligent space integrating technology, comfort and entertainment. Extremely Fox Alfa T5, a brand-new masterpiece of Extremely Fox Automobile, has successfully interpreted the new concept of "mobile entertainment room" with its excellent performance, intelligent configuration and luxurious and comfortable cockpit design, bringing unprecedented experience to family travel.

Extreme Fox Alpha T5 intelligent technology, leading the future driving.

Extreme Fox Alpha T5 is equipped with the second-generation intelligent cockpit control platform developed by Extreme Fox and equipped with Qualcomm Snapdragon 8155 chip. This powerful heart provides a solid foundation for the intelligent experience of the whole vehicle. With the 15.6-inch high-definition central control screen, not only the visual effect is shocking, but also the operation fluency has reached an unprecedented height. It is reported that the large screen supports a variety of interactive modes, whether it is touch control or voice control, which can be easily realized, greatly improving the convenience and safety of driving.

It is particularly worth mentioning that the Extreme Fox Alpha T5 also supports the four-tone voice interaction function, which means that both drivers and passengers can operate the vehicle through voice commands, without worrying about mistaken recognition or omission of commands. This design fully considers the actual needs of family travel, so that every passenger can enjoy intelligent convenience.

Extreme Fox Alpha T5 luxury cockpit, enjoy a comfortable experience.

As soon as I stepped into the carriage of the polar fox Alpha T5, the breath of luxury and comfort came to my face. The car is wrapped and decorated with high-grade materials, and both the tactile and visual effects have reached a very high level. It is particularly worth mentioning that the polar fox Alpha T5 has also made great efforts in health and environmental protection, and the content of harmful substances in its compartment is extremely low, almost reaching the standard of zero formaldehyde and zero benzene, providing passengers with a healthy and fresh riding environment.

In addition, the Extreme Fox Alpha T5 is also equipped with a number of luxury configurations, such as seat heating/ventilation, panoramic sunroof, etc., which further enhances the comfort and convenience of riding. In particular, its ultra-quiet design makes the noise level in the car extremely low, and it can maintain a quiet and comfortable riding environment even when driving at high speed.

Extreme Fox Alpha T5 is powerful and easy to control.

In terms of power, the polar fox Alpha T5 also performed well. It is equipped with a high-performance motor with a maximum horsepower of 272ps. With the advanced power system and intelligent four-wheel drive technology, the vehicle can maintain excellent power performance and handling stability in various road conditions. According to official data, the 0-100km/h acceleration time of the Extreme Fox Alpha T5 can be completed in just a few seconds, which is comparable to many luxury brands.

During the actual test drive, the author deeply felt the strong power of the Extreme Fox Alpha T5. Whether it is accelerating at the start or overtaking in the middle, it can be easily handled. At the same time, its handling is also impressive, with precise steering and solid chassis, and it can maintain a stable posture even when driving at high speed.

Extreme Fox Alpha T5 intelligent entertainment, enjoy a pleasant journey.

In addition to excellent power and handling performance, the Extreme Fox Alpha T5 also performed well in the entertainment system. It has built-in rich entertainment applications and resource libraries for passengers to choose and use. Whether watching high-definition videos, listening to high-quality music or playing games can be easily realized. In addition, this model also supports the function of mobile phone interconnection, so that passengers can project the entertainment content on their mobile phones to the central control screen for viewing and operation at any time.

It is particularly worth mentioning that the Extreme Fox Alpha T5 is also equipped with an advanced cloud game platform, providing more than 1,000 selected games for passengers to choose from. During long-distance travel, passengers can enjoy an immersive game experience in the car by connecting devices such as game consoles or mobile phones, as if they were in a mobile private game cabin.

To sum up, the Extreme Fox Alpha T5 has successfully promoted family travel to a new height with its excellent intelligent configuration, luxurious and comfortable cockpit design and strong power control performance. It is not only a car, but also a mobile entertainment room integrating technology, comfort and entertainment, bringing unprecedented travel experience to passengers. I believe that in the future market competition, Extreme Fox Alpha T5 will win the favor and recognition of more consumers with its excellent quality and performance.

Lexus RX price reduction news in Guangzhou, discount 10,000! Plenty of cars

Welcome to [Autohome Guangzhou Discount Promotion Channel], we bring you the latest promotion information of the model. At present, the Lexus RX in Guangzhou is undergoing an unprecedented price reduction activity, with the highest discount reaching an astonishing 10,000 yuan, making the luxury SUV originally priced at 395,000 yuan to reach a more attractive price point. If you are interested in the Lexus RX, don’t miss this rare opportunity. Click "Check the car price" in the quotation form now, and let us help you get the most accurate discount details and car purchase suggestions to seize this rare car purchase opportunity.

广州地区雷克萨斯RX降价消息，优惠1万！现车充足

The exterior design of the Lexus RX fuses elegance and power, revealing the brand’s unique luxury temperament. The front face is sharply designed, with a family-style spindle-shaped air intake grille and LED headlight sets, giving the vehicle a striking recognition. The overall style is smooth and sporty, with clear lines, creating a strong dynamic beauty. The side profile of the body is full, highlighting the stability and power of a premium SUV. Whether it is the details or the overall shape, the Lexus RX fully demonstrates its exquisite craftsmanship and excellent design concept.

广州地区雷克萨斯RX降价消息，优惠1万！现车充足

The Lexus RX is elegant with its refined side design. The body size is 4890mm*1920mm*1695mm and the wheelbase reaches 2850mm, ensuring a large interior space and good driving stability. The side lines are smooth and full of power, and the 235/60 R19 size tires provide excellent driving performance and visual effect. The choice of tires focuses on comfort and grip, while the wheel design continues the luxury of the Lexus brand.

广州地区雷克萨斯RX降价消息，优惠1万！现车充足

The interior design of the Lexus RX is designed with attention to detail and luxury, showing the exquisite quality unique to the brand. The steering wheel is made of genuine leather, which feels comfortable to hold and supports electric up, down and front and rear adjustment to ensure the best operating experience for the driver. The central control area is equipped with a 9.8-inch touch screen, which is clear and easy to use. It integrates functions such as multimedia system, navigation, phone and air conditioning, and supports automatic speech recognition control, which enhances the convenience of the driving process.

In terms of seats, both the main driver and the co-pilot are made of imitation leather, providing front and rear, backrest, high and low multi-directional adjustment functions, including waist support, to ensure passenger comfort. The second row of seats also supports backrest adjustment, while the rear seats support proportional reclining, providing passengers with flexible space layout and storage options. The overall interior design combines practicality and luxury, fully reflecting the interior highlights of the Lexus RX.

广州地区雷克萨斯RX降价消息，优惠1万！现车充足

The Lexus RX is equipped with a 2.5L four-cylinder engine capable of delivering a maximum power of 139 kilowatts and a peak torque of 241 Nm. This powertrain uses an E-CVT continuously variable transmission, providing a smooth driving experience and good fuel economy.

Overall, Autohome owners are full of praise for the appearance of the Lexus RX, believing that it shows the perfect combination of luxury and stability. The unique front face design and elegant body lines make it stand out in traffic and attract attention. For drivers who pursue individuality and quality, the Lexus RX is undoubtedly a highly recognizable choice.

IVECO： A new company will be established from the CNHI Group!

On September 3, 2019 local time, CNH Industrial N.V. held a Capital Markets Day event at the New York Stock Exchange and announced several blockbuster announcements.