分类： ee

Settle in 16 enterprises to create a new economic growth point in Guangyuan

—— On-the-spot report of Guangyuan JAL electromechanical high-tech industrial park project

Pavement leveling operation

Worker Yang Ziquan is carrying out board survey.

Open column language

2018 is the first year to study and implement the spirit of the 19th National Congress of the Communist Party of China, and it is also the year to deepen the city’s work style and discipline. Faye Wong, secretary of the Municipal Party Committee, pointed out at the mobilization meeting of the year to deepen the city’s work style and discipline: we should focus on large projects to promote large-scale development, carry out in-depth "big competition in projects" activities, grasp large projects, grasp large projects, and implement various cooperation such as Chengdu-Guangzhou cooperation, so as to promote a number of key projects to settle in Guangyuan at a higher level and truly form a pattern of large-scale opening and cooperation.

What should be done about the "annual competition of projects"? From now on, this newspaper will set up the column of "Annual Competition of Projects" and send reporters to the construction site to follow up on the progress of major projects in our city, so please pay attention.

Project business card

Rihang electromechanical high-tech industrial park

The proposed investment of the project is 4 billion yuan, with a total planned area of more than 800 mu and a construction area of about 700,000 ㎡. The project planning is divided into three parts: first, the layout of the factory area of small and medium-sized enterprises (production houses); Second, supporting accommodation, office buildings, canteens and medical education in the park; The third is the micro-enterprise incubation building, warehousing and logistics. The proposed construction period is 5 years, and the completion time is at the end of 2020. After the completion of the project, the annual main business income will be 4 billion yuan, the annual profit will be 500 million yuan, the annual tax revenue will be 350 million yuan, and more than 3,000 local jobs will be provided.

Image progress

Up to now, the project has invested 1.376 billion yuan, the exhibition center of Building 10-3 has been put into use, and the 10-1# and 10-2# complex buildings are being decorated and decorated on the fa? ade. It is expected to be put into use in September this year to solve the staff accommodation problem. In addition, the main body of the garden-style workshop of the project started construction of 58,000 square meters, of which 30,000 square meters of "customized workshop" is in the finishing decoration stage, and equipment installation began in June this year. In addition, 28,000 square meters of workshops of Sichuan JAL, Weilingma and other enterprises are being accelerated. It is planned to install the equipment in October this year and put it into commissioning.

Live close-up

Builders under high temperature

In the early summer, the sun is like fire, and there are crowds of people on the newly leveled ground with the fragrance of earth.

At the construction site of the mechanical and electrical high-tech industrial park in Guangyuan, the construction workers fought in the scorching sun to compete with the high temperature in order to ensure the smooth completion of the project.

There are 6 excavators, 4 road rollers, 3 loaders and more than 30 trucks. Every day, more than 300 workers are working at the scene, and the project leaders and enterprise managers are walking back and forth in the park, and the sound of the machine is rumbling and busy.

Walking into the No.8 construction plant, the sweltering heat came to my face, and the reporter soon sweated like rain, and soon the sweat soaked his eyes. The workers are so absorbed in the wall work that they can’t take care of the sweat on their foreheads.

Close to the welding site, the welder wears a helmet on his head and his face, body and feet are wrapped in thick protective clothing. It can be felt that the temperature at the welding site is much higher than that in other places. "An electric welding is about 20 kilowatts, and the staff is working in such hot weather." Ting Huang, project manager of the industrial park, told the reporter.

The reporter wanted to interview the welding workers, but two or three people were refused. Ting Huang told reporters that they are racing against time to catch up with the progress, to ensure the accuracy of each welding position, to ensure that no welding spot is missed, and to try to grab the working hours for one or two hours before noon, so that they don’t have to work at the hottest time.

Not far away, Zhang Yonggui, the young man who directed the vehicle counting, kept fanning his exercise book. The reporter stepped forward and humorously teased his dark skin. Zhang Yonggui told the reporter with a smile that he was from Mianyang. He was 27 years old and went to the construction site in November 2016. "Look at my sunburned arms and legs. I usually don’t dare to wear shorts when I go to a friend’s party. It’s too dark to see anyone." Zhang Yonggui said that the conditions on the construction site are difficult, and he must temporarily give up the nature of young people’s love for beauty and complete the task.

As for the details of the project, Ting Huang introduced that the factory building in the park adopts a frame structure, which is superior to the ordinary factory building in terms of price and 15 years longer in service life than the ordinary factory building. What’s more worth mentioning is that the garden-style decoration style is adopted in the park. For environmental protection reasons, vegetation is planted on the roof to present a new ecological industrial park.

It’s not noon yet, and the rising temperature has brought a severe test to the project construction, but every construction site still has builders who stick to their posts and concentrate on their work every day. The staff of the major engineering headquarters also share joys and sorrows with the workers, directing and supervising operations at the construction site to ensure that the project is completed on time.

Pushing measures

Accelerate the realization of the established goal of "early completion, early production and early competition for benefits"

On September 29, 2015, Zhejiang JAL Power Technology Co., Ltd. signed a tripartite investment agreement with Guangyuan Municipal People’s Government and Lizhou District People’s Government of Guangyuan City to build Guangyuan JAL Electromechanical High-tech Industrial Park, which is a provincial and municipal key investment attraction project.

As a designated project contacted by Faye Wong, secretary of the municipal party committee, Faye Wong, secretary of the municipal party committee, instructed to realize the established goal of "early completion, early production and early competition for benefits", speed up the construction progress of garden-style factory buildings in the industrial park, and show the spirit of "showing strength and seeing benefits".

According to statistics, there are 7 enterprises currently settled in the park: Weilingma Electronics Co., Ltd., Sichuan JAL Electronic Technology Co., Ltd., Sichuan Xindadi Electrical Equipment Co., Ltd., Guangyuan Tianying Precision Transmission Co., Ltd., Guangyuan Jinchuang Electronic Technology Co., Ltd., Guangyuan Yingsheng Electromechanical Equipment Co., Ltd. and Guangyuan Shuheng Electromechanical Equipment Co., Ltd. The main products are solar cell back film, electronic power and mobile phone chip, mobile phone motherboard and mobile phone assembly, auto parts and so on. In 2018, it plans to successfully attract 6 companies and is currently actively negotiating.

In order to speed up the project, the Management Committee and the Project Department hold two or three coordination meetings of key projects every month to keep abreast of the progress of key projects, sort out and analyze the crux of influencing and hindering the project progress, study the countermeasures to solve the problems, coordinate and solve the difficulties and problems encountered in the project promotion process, and ensure that the project construction is advanced as expected; At the same time, further optimize and improve the investment environment, re-investigate and re-resolve the contradictions and disputes arising in the process of enterprise construction and production, rectify and standardize the market economic order, protect the legitimate rights and interests and personal safety of investors according to law, and create a good investment and development environment for enterprises in the park.

Reporter’s notes

The pace of "strengthening" the industry is forceful.

The key to strong industry lies in industry.

According to the law and present situation of economic development, to adapt to, grasp and lead the new normal of economic development, the electromechanical industry in our city also guarantees excellent projects from supporting leading enterprises, establishing industrial groups, increasing investment attraction, establishing professional industrial zones for substation equipment production, and attaching importance to talent introduction and training.

At the same time, the city regards "strong industrial development" as the best choice, and investment promotion cadres actively move to find ways and excellent services; At the scene of each key project, the workers stepped up their construction, and the scene was full of enthusiasm … During the interview, the reporter felt the vigorous vitality and endless power of the city’s industrial development.

Standing at a new starting point, all departments at all levels in our city are further inspiring the courage to dare to compete, the atmosphere of being good at learning and the ambition to catch up, igniting the passion of catching up with learning, urging contracted projects to invest and put into production early, helping landing enterprises to innovate and benefit more, and consolidating the industrial foundation. The whole city has steadfastly and consistently grasped the unrelenting momentum of developing industries, making the pace of "strengthening industries" more forceful.

(Reporter Zhao Jingmei)

　　Financial Morning Bus | Reproduce 1000 shares after 27 years! "King of Shares" Maotai rushed to 1001 yuan.

　　Today’s guide

　　1. The three major US stock indexes were mixed, and the price of gold fell for two consecutive trading days.

　　2. Ministry of Commerce: The Sino-US economic and trade teams keep in touch and make economic and trade preparations for the meeting between the two heads of state in Osaka.

　　3. Central Bank: The growth momentum of leverage ratio has been initially curbed, and the prevention and control of financial risks has been steadily and decisively promoted.

　　4、0.06%！ Science and technology innovation board’s first share winning rate was announced, and 2.76 million investors participated in the innovation.

　　5. After a lapse of 27 years, A shares reappear in thousands of shares! Maotai’s share price broke through 1000 yuan and hit a new high.

　　6. Shenzhen Stock Exchange: Support SMEs to use the capital market for direct financing.

　　7. Net purchase of northbound fundsZTE (000063.SZ)343 million yuan

　　8. Hot-spot mortgage interest rates in second-tier cities are loose and tight, which is the norm because of the city’s policy.

　　I. Global market

　　On Thursday, Eastern Time, European and American stock markets were mixed, with the Dow down 0.04%. Us oil rose slightly, hitting a new high for more than a month; Gold prices fell for the second consecutive trading day.

　　US stocks: The three major US stock indexes were mixed, with the Dow down slightly by 0.04%, the Nasdaq up by 0.73% and the S&P up by 0.38%.

　　Gold: The international gold price closed down slightly, falling for the second consecutive trading day. At the close, the most active August gold futures closed at $1,412 an ounce, a decrease of 0.24%.

　　Crude oil: US oil closed slightly higher, hitting a new high for more than a month. At the close, WTI crude oil futures in August closed 0.08% at $59.43 per barrel; Brent August crude oil futures closed up 0.09% at $66.55/barrel.

　　London copper: London copper closed up 0.24% at $6002.50/ton.

　　Second, the news express

　　Ministry of Commerce: The Sino-US economic and trade teams maintain communication and make good economic and trade preparations for the meeting between the two heads of state in Osaka.

　　Gao Feng, spokesman of the Ministry of Commerce, said at a regular press conference on the 27th that the leaders of China and the United States had a good conversation on June 24th, and since then, the economic and trade teams of the two sides have continued to keep in touch and communicate. At present, the economic and trade teams of the two sides are communicating in accordance with the instructions of the two heads of state to make economic and trade preparations for the meeting between the two heads of state in Osaka.

　　Central Bank: The growth momentum of leverage ratio has been initially curbed, and the prevention and control of financial risks has been steadily and decisively promoted.

　　The 85th regular meeting of the Monetary Policy Committee of the People’s Bank of China in the second quarter of 2019 was held in Beijing on June 25th. The meeting held that the RMB exchange rate was generally stable and its ability to cope with external shocks was enhanced. Steady monetary policy reflects the requirements of countercyclical adjustment, the rapid growth of macro leverage ratio has been initially curbed, the prevention and control of financial risks has been steadily and decisively promoted, and the quality and efficiency of financial services to the real economy have gradually improved.

　　0.06%！Science and technology innovation board’s first share winning rate was announced, and 2.76 million investors participated in the innovation.

　　At present, there are more than 2.7 million individual investors who have opened the trading authority in science and technology innovation board. It is the first time for them to make new investments in science and technology innovation board. How about the participation of these investors? According to the data provided by Shanghai Stock Exchange, there are 2,756,300 effective subscription households and 19,154 million shares in this online offering, and the initial success rate of online offering is 0.039777%.

　　After a lapse of 27 years, A shares reappear in thousands of shares!Maotai’s share price broke through 1000 yuan and hit a new high.

　　On Thursday (June 27th), Kweichow Moutai (600519.SH) opened higher and went higher, and its share price reached a new high, successfully breaking through the thousand yuan mark, hitting a maximum of 1,001 yuan in intraday trading. As of the close, Kweichow Moutai’s share price was 996.35 yuan, up by 1.68%, with turnover exceeding 4.7 billion yuan.

　　It is worth mentioning that Kweichow Moutai is not the first A-share stock to break 1,000 yuan. In the early 1990s, in the initial stage of China stock market, there were two stocks exceeding 1,000 yuan — — Vacuum Electronics (now Yunsai Zhilian (600602.SH)) and Feile (now *ST Zhongan (600654.SH)).

　　Shenzhen Stock Exchange: Support SMEs to use the capital market for direct financing.

　　On June 26th, Shenzhen Stock Exchange and China Electronic Information Industry Development Research Institute of Ministry of Industry and Information Technology jointly hosted the 16th China Expo SME Investment and Financing Forum and Investment Roadshow. In the next step, Shenzhen Stock Exchange will continue to play the role of a multi-level capital market platform, deepen market reform, strengthen the construction of basic systems, increase the supply of innovative products, enhance the breadth and depth of market services, support small and medium-sized enterprises to use the capital market for direct financing, provide more facilitation measures to alleviate the difficulties of small and medium-sized enterprises, and help more small and medium-sized enterprises to innovate, develop and become bigger and stronger.

　　Northbound capital net bought ZTE 343 million yuan.

　　The northbound capital ended the net outflow trend for three consecutive days, with a net inflow of 3.8 billion yuan yesterday (June 27). In terms of individual stocks, northbound funds bought a net of 343 million yuan from ZTE, and bought more than 200 million yuan from Hikvision (002415.SZ) and Ping An Bank (000001.SZ).

　　Hot-spot mortgage interest rates in second-tier cities are loose and tight, because the city’s policy is the norm.

　　Since June 15th, the mortgage interest rates of the first and second suites in Chengdu, Tianjin, Fuzhou, Suzhou, Nanning, Hangzhou, Wuhan and other places have been raised to varying degrees, and some cities have experienced the phenomenon of tight mortgage amount and longer loan period. Market analysts believe that the mortgage interest rate has been moderately reduced with the overall easing of the market, but this round of mortgage interest rate reduction is basically coming to an end, and mortgage interest rates in many cities have bottomed out, which shows that the wind direction of financial lending policies has changed, including lending behavior and housing trading behavior in the future.

　　Third, Tianxia Company

　　Yiming Pharmaceutical (002826.SZ): Huajin Tianma intends to reduce its shareholding by no more than 6%.

　　Wansheng shares (603010.SH): The actual controller and senior management intend to reduce their holdings by no more than 4.65%.

　　Saiyi Information (300687.SZ): Zhuhai Gaoying intends to continue to reduce its shareholding by 3%.

　　Zhejiang Energy Power (600023.SH): The controlling shareholder plans to exchange 3% of the shares for the Yangtze River Delta ETF.

　　Wantong Technology (002331.SZ): The controlling shareholder increased its shareholding by 1.96%.

　　Hezhong Stronghold (002383.SZ): It is planned to introduce state-owned capital shareholders, and the actual controller will be changed.

　　Lida Optoelectronics: abbreviation changed to "China Optics (002189.SZ)" from 28th.

　　China CITIC Bank (601998.SH): It plans to subscribe for 1.4 billion shares of CITIC baixin bank.

　　*ST Xinwei (600485.SH): the suspension will not exceed 10 trading days.

　　*ST Southeast (002263.SZ): Resumption of trading, application for cancellation of delisting risk warning.

　　ST Yinyi (000981.SZ): The proposal of "Performance Compensation Implementation Plan" was rejected by the shareholders’ meeting.

　　Fourth, hot prospects

　　1、In May, the profits of industrial enterprises picked up, and the profits of equipment manufacturing industry improved significantly.

　　According to the data released by the National Bureau of Statistics on the 27th, the total profit of industrial enterprises above designated size increased by 1.1% year-on-year in May, and the growth rate turned from negative to positive. The positive impact of government tax reduction and fee reduction on corporate balance sheet support is gradually emerging, which is conducive to the recovery trend of industrial enterprises’ profits. In the future, with the further implementation of counter-cyclical adjustment policies to support the macroeconomic environment, the profits of industrial enterprises are expected to be further repaired.

　　Related stocks: Related companies include Huatie (000976.SZ), Hengli Hydraulic (601100.SH), Zhonghuan (002129.SZ) and North Huachuang (002371.SZ).

　　2、The power generation and consumption plan will be fully liberalized, and the power reform will usher in the era of market-oriented trading.

　　The National Development and Reform Commission (NDRC) issued a notice on the 27th to fully liberalize the power generation and consumption plans of operating power users and improve the marketization of power transactions. Except for the power users in the industries of residents, agriculture, important public utilities and public welfare services, as well as the auxiliary power and line loss necessary for power production and supply, other power users belong to operating power users. The document also encourages power users and power generation enterprises to determine the specific price in a flexible and floating form when signing contracts through independent consultation, and the price floating method is agreed by both parties in advance.

　　Related stocks: Wenshan Electric Power (600995.SH) continued to strengthen the guidance and service of electricity market-oriented trading, and completed the trading power of 3.576 billion kWh last year; Jidian (000875.SZ), Zhangze Electric Power (000767.SZ) and Chendian International (600969.SH) also invested and set up subsidiaries engaged in electricity sales.

A rare heat wave is raging in the northern hemisphere. At 6 o’clock on August 22, the Central Meteorological Observatory issued the highest level warning of high temperature in China-high temperature red warning for the 11th consecutive day. Not only in China, but also in Spain, Portugal, France, Britain and other places, heat waves with high temperature exceeding 40℃ have broken through historical extremes in many places, threatening human health, power supply, agricultural production and water resources.

Why is the heat wave coming? Will extreme weather become the norm in the future? According to the meteorologists interviewed, it is very rare to see the intensity and frequency of extreme weather this year. In addition to short-term direct meteorological factors, there has been a lot of evidence that this is closely related to long-term climate change. Climate change has once again sounded the alarm for the whole world.

High temperature and heat waves generally hit the northern hemisphere, and temperatures in many countries broke historical records.

The whole world is as cool and hot as this-at this moment, people in the whole northern hemisphere feel it particularly vividly.

"China has experienced the strongest high temperature process since there was a complete meteorological observation record in 1961. This process has the characteristics of long duration, wide range, high intensity and strong extremes." According to Zhou Bing, chief expert of climate service of the National Climate Center, as of August 21st, the duration of high-temperature events in China this summer (70 days), the coverage of high-temperature areas above 40℃ (1.5 million square kilometers), the maximum temperature intensity of a single station (45℃) and the number of stations with historical extremes broken or flat by the National Meteorological Station (330 stations) all set new records.

Looking around the world, the crimson and orange on the temperature map symbolize the high temperature weather above 35℃, which are widely distributed in Europe, North Africa, North America, East Asia and other places. In just one month, Europe experienced two rounds of heat waves. According to the World Meteorological Organization, the current heat wave sweeping Europe will continue, and the negative effects of climate change such as high temperature will last at least until the 1960s.

The decrease of river water level, the increase of forest and grassland fire risk, the drought of crops, the shortage of power and water resources … The heat wave brings not only somatosensory heat, but also a series of secondary disasters.

The unusually high temperature and rainfall are significantly less than in previous years, and the drought in many places in Europe is serious. "From the dry and cracked reservoirs in Spain to the drop in water levels of major rivers such as Danube, Rhine and Po, an unprecedented drought is sweeping across nearly half of Europe." The Associated Press reported that there was no obvious precipitation in most parts of continental Europe in the past two months, and some experts called it "the worst drought in 500 years".

The high temperature and drought caused the river water level to drop seriously, and the riverbed was exposed, making it difficult for ships to sail. The Rhine River is an important inland waterway in Europe, which flows through Germany, France, the Netherlands, Switzerland and other countries and is known as the "golden waterway". German federal and local waterway and shipping management agencies have warned many times recently that the waterway water level near many cities along the lower reaches of the Rhine River has set a new record, which has led to a sharp decrease in shipping volume and the actual load of ships is less than half of the normal situation.

Long-term high temperature combined with protracted drought has sharply increased the threat of forest fires. According to the data of the European Forest Fire Information System, more than 50,000 hectares of forests in France have been burned by fires this year, which is more than three times the average level in the past decade. Large-scale forest fires have also occurred in California, USA.

In the Po River region of Italy, severe drought caused rice fields to dry up and lack water. Local farmers estimate that this year’s rice harvest may be "halved". The German Farmers’ Association recently warned that in the case of continuous drought, we should be alert to crop failures and price increases. If it doesn’t keep raining as soon as possible, the harvest may be reduced by 30% or 40%.

Extreme high temperature also poses a threat to human health. "Heat will cause disease, and heat stress and high concentration of ground ozone will have a serious impact on health." Klaus reinhart, president of the German Medical Association, said about the impact of this wave of heat waves in Europe. The French health department warned that during the heat wave, the number of people seeking medical treatment increased significantly due to overheating and dehydration.

　Climate warming intensifies the instability of the climate system and is more likely to lead to extreme weather and climate events.

Why is the high temperature event "long standby"? Meteorological observations can provide direct and short-term explanations. High temperatures are often caused by specific weather systems, the most common of which is subtropical high. The area under its control is prevalent in downward flow. On the one hand, air subsidence will compress and warm up; on the other hand, the upward movement is weak, and there is little rain in partly cloudy.

"The extreme high temperature in the northern hemisphere is caused by multiple factors, and the continuous abnormal atmospheric circulation is a direct cause." Zhou Bing told reporters that the western Pacific subtropical high belt, the Atlantic high belt and the Iranian high pressure have all been strengthened in stages, thus forming a large-scale warm and high pressure belt around the northern hemisphere, which makes the hot air stay near the ground and cannot be dispersed, and then there is a high-temperature heat wave event.

La Nina climate events have contributed to the atmospheric circulation anomalies. La Nina refers to the phenomenon that the seawater in the equatorial, Middle East and Pacific Ocean is unusually cold, which can cause changes in atmospheric circulation and then affect the climate. "Since this spring, the La Nina event in the equatorial eastern Pacific has intensified, and the SST anomaly in the Indian Ocean has pushed the subtropical high to continue to increase." Zhou Bing said.

Considering from a longer climate scale, global warming is the background of high temperature heat wave in the northern hemisphere. The long-term climate change caused by human activities is the deep-seated reason for the increase in the frequency and intensity of extreme weather.

"Climate warming will change the global ocean and atmospheric circulation situation, and further affect the local climate through the interaction between ocean and atmosphere, land and atmosphere. Climate warming intensifies the instability of the climate system and is more likely to lead to extreme weather and climate events. " Chao Qingchen, director and researcher of the National Climate Center, told the reporter that the overall feature of climate change is to aggravate the instability of the global climate, and the impact and risks on natural ecosystems and economic and social systems are becoming increasingly serious.

According to the sixth assessment report of the United Nations Intergovernmental Panel on Climate Change (IPCC), global warming is occurring at an unprecedented rate since 2000 in the last 50 years. The report released by the World Meteorological Organization shows that in the past 50 years, due to the impact of climate change, the number of disasters has increased fivefold and the disaster losses have increased more than sevenfold.

"Climate change has led to a trend of frequent, extensive, strong and concurrent extreme weather and climate events." Zhou Bing mentioned that the compound disasters caused by extreme weather are increasing. High temperature, heat wave and drought may occur more frequently, accompanied by the risk of wildfire; In some places, the possibility of compound flood has increased, and this possibility will continue to increase due to rising sea level and increasing precipitation intensity.

According to Zhou Bing’s observation, compared with several high-temperature events since the beginning of this century, this year’s heat wave has an obvious trend of advancing and strengthening in both the starting time and the extreme degree.

In the future, will the "hottest" become the norm?

According to the World Meteorological Organization, due to the influence of climate change, it is expected that extreme high temperatures will appear more frequently and more strongly in the future. Nalis, a spokesman for the organization, said that if greenhouse gas emissions continue to rise, global warming will be even greater, and what we are experiencing now is only a "harbinger of the future".

"Due to the intensification of global warming, the frequency of events such as extreme high temperature and extreme heavy precipitation has accelerated and the cycle has been shortened. The original once in 50 years has become once in 20 years or even 10 years. Every 1℃ increase in global temperature leads to an increase of 7% in extreme precipitation intensity. Every 0.5 C warming in the future will significantly change the frequency of extreme temperature events. " Zhou Bing said that the extreme high temperature staged in the world may herald the coming of the "40 C era in the northern hemisphere", but this needs further observation and scientific confirmation.

　Rare extreme weather has sounded the alarm for the whole world, and it is urgent to deal with climate change.

The heat wave even rushed to the polar regions. "The temperature in Greenland is close to 60 degrees Fahrenheit (about 15.5 degrees Celsius), and warm weather like today is enough to wear short sleeves." On July 19th, in Greenland, an extremely cold place, a reporter appeared in the news screen wearing a thin T-shirt.

Greenland is the largest island in the world, most of which is located in the Arctic Circle, and about 80% of the island’s land is covered by ice sheets. This summer, the temperature in the Arctic Circle soared to 32.5℃, and the ice sheet in Greenland is melting at an alarming rate. According to data from the National Snow Data Research Center, from July 15th to 17th, the Greenland ice sheet lost about 6 billion tons of ice every day, enough to fill 7.2 million Olympic swimming pools. If the negative effects of climate change such as high temperature continue, the Greenland ice sheet will melt completely and the global sea level will rise by 7.5 meters.

In mid-March this year, the temperature in some parts of the Arctic was about 30℃ higher than the average level in the same period of last year. Many research stations in Antarctica have measured record high temperatures. The temperature at Concordia Antarctic research station is about 40℃ higher than the average level in the same period of last year, and the temperature at Kunlun Station in Antarctica in China has increased by 38.1℃ within 4 days. "The seasons in the north and south poles are opposite, but it is rare to see extreme hot weather at the same time. This is absolutely unusual." Zhou Bing said.

All kinds of unusual things have sounded the alarm for the whole world.

The research of Nobel Prize winners in physics, Shuro Kuniko and Klaus Hasselman, intuitively pointed out the relationship between greenhouse gas emissions and global warming: if the atmospheric carbon dioxide concentration doubles, the global average temperature will rise by more than 2℃. Accordingly, the Paris Agreement puts forward the goal of "keeping the global average temperature rise within 2℃ relative to the pre-industrial level by the end of this century and making efforts to control the global average temperature rise within 1.5℃".

Significantly reducing greenhouse gas emissions is related to the future and destiny of mankind. In 2021, the global average temperature was 1.11℃ higher than the pre-industrial level. In April this year, the IPCC said through the report of Working Group III in the Sixth Assessment Report that the world is at a crossroads where it is now or never. "If you want to control global warming within 1.5℃, you should either act now or never (fail to meet the standards), so all departments need to carry out deep emission reduction." Jim Ski, co-chairman of Working Group III, said.

"China has actively participated in global climate governance, implemented a national strategy to deal with climate change, promoted industrial restructuring and energy structure optimization, and accelerated the construction of a’ double carbon’ policy system, and achieved remarkable results in carbon emission reduction." According to Zhou Bing, in the past decade, China’s energy consumption intensity has been reduced by 26.2%, which is equivalent to using about 1.4 billion tons of standard coal less and emitting about 2.94 billion tons of carbon dioxide less. In 2020, China’s carbon emission intensity will decrease by 18.8% compared with 2015 and 48.4% compared with 2005, exceeding the target of 40%-45% promised to the international community.

The unbearable heat has also made people have a more real experience of global warming. "In terms of emission reduction, we often say that there are five levels: international social experience and mutual cooperation, national or regional independent contributions and policy-level attention, industry and enterprise carbon emission constraints and efforts, active participation of communities and the public, and scientific dissemination of green and low-carbon concepts of associations." Zhou Bing said that the public is not detached from the issue of climate change, and energy conservation and emission reduction require the joint efforts of all walks of life in the whole society.

Pay equal attention to mitigation and adaptation, enhance climate resilience and build a climate-adaptive society.

Reducing emissions is not the only action to deal with climate change. Mitigation and adaptation are two major strategies to deal with climate change, which complement each other and are indispensable.

"Mitigation refers to reducing greenhouse gas emissions through long-term adjustment of economic systems and natural ecosystems such as energy and industry. Adaptation refers to the climate change that has occurred and is expected to occur, through the adjustment of natural systems and human systems, to reduce the adverse effects of climate change on social and economic development and ecosystems, and to make full use of favorable factors. " Nest clearing dust said.

Slow down is the fundamental solution, but adaptation is also essential to solve the immediate problems. In the view of Chao Qingchen, the necessity can be understood from two aspects: first, climate change has already occurred, and its negative impact cannot be minimized if it is not adjusted and changed through adaptive means. Secondly, it takes time for mitigation measures to have an effect. Greenhouse gases have a long "life span". Even if emissions are reduced, past and present emissions will continue to affect the climate system, and the consequences will be manifested for a long time, such as sea level rising in the next few hundred years. Therefore, for the risks that have occurred and are about to occur, we must rely on adaptive measures to reduce the adverse effects.

China has always been adhering to the concept of paying equal attention to mitigation and adaptation, and taking active adaptation to climate change as an important part of implementing the national strategy of actively responding to climate change. Not long ago, the National Climate Change Adaptation Strategy 2035 was released, and it was proposed that by 2035, "a climate-adapted society will be basically completed".

Huang Gang, a second-level researcher in lasg, said in an interview with this reporter that according to the Action Plan for Urban Adaptation to Climate Change, the goal of building a climate-adapted city is to "significantly enhance the city’s ability to cope with waterlogging, drought and water shortage, high-temperature heat waves, strong winds and freezing disasters, and comprehensively improve its ability to adapt to climate change". "Similarly, a climate-adaptive society is a society with strong adaptability under changing climate conditions."

Try your best to prevent, focus on reducing, enhance climate resilience, and improve disaster prevention and mitigation capabilities. "Strengthening the early warning of extreme weather and climate events is the first line of defense for disaster prevention and mitigation." Chao Qingchen said that in the future, it is necessary to strengthen the comprehensive on-the-spot monitoring of extreme weather and climate and the understanding of the fine characteristics of disastrous weather and climate. Zhou Bing believes that global warming has brought new challenges to meteorological disaster prevention and mitigation, and it is necessary to continuously strengthen the disaster risk management ability of the whole society and the public’s awareness of disaster prevention and mitigation to minimize the impact of disasters.

Many interviewed experts said that in the face of increasingly frequent and intense extreme weather, we should not only focus on the present and solve the immediate problems, but also focus on the long-term and make a comprehensive response. For example, extreme weather affects agricultural production and energy supply, so we should take precautions and prepare adequate countermeasures. For another example, urban planning should take extreme precipitation and extreme high temperature into consideration, build infrastructure such as flood control and drainage systems that can withstand extreme weather, provide more shade places, and use more environmentally friendly and heat-insulating building materials.

The heat wave will eventually ebb, but the climate problem will not disappear, and extreme weather will not disappear. The challenges brought by climate change to mankind are realistic, severe and long-term, and each of us has the responsibility to "cool down" the earth.

(Author: Chai Yaxin Editor: Xu Nenyu)

10086, 12306, major banking service hotlines … …

These calls will be made whenever there is a problem or business.

Life seems to have formed an indissoluble bond with them

The problem solved.

Trust is slowly established.

we

All the time

Experiencing

service

Bring convenience and beauty.

Sometimes the service is small, as small as an action, and sometimes it is big, so big as to represent the overall image of an enterprise. As a state-level and high-tech enterprise in Zhongguancun, Guoneng Rixin has always adhered to the service tenet of "customer first, technological innovation and excellent service", and has continuously expanded its service team, which has witnessed our attitude of service innovation and development. At the same time, as a service hotline between Unicom enterprises and customers, it also plays an extremely important role. Therefore, the national customer service hotline of Guoneng Rixin was officially opened, and the announcement is as follows:

So, what convenience can our customer service center bring to customers?

Provide after-sales service

The customer service center mainly solves after-sales problems for customers. When customers have after-sales service needs and feedback, they can call 400 customer service at any time. The problems will be recorded and received by the customer service staff of the special line, and handled by the professional technical service team, and customers will be arranged to pay a return visit regularly to maintain close communication with customers.

The customer service center will provide 7*24 hours full service, and we will serve you with enthusiasm, patience, careful attitude and professional technology, and answer every call with our heart.

Product consulting service

The customer service center provides product consulting services, and customers can learn about the required products and services through the 400 service hotline. At present, we often receive inquiries about the company’s wind/light power forecasting system, AGC/AVC system, distributed photovoltaic/photovoltaic poverty alleviation power station operation management platform, intelligent monitoring/resource evaluation and other products. Through 400 calls, customers can learn more about the products and services they need.

If you are our partner, have after-sales service needs in the station, or want to know about our products, you are very welcome to call our national customer service hotline at 400-6688-760, and we will serve you wholeheartedly and become a lifelong partner with you.

Say the important things three times,

Remember to call me if you have anything!

400-6688-760

400-6688-760

400-6688-760

We are the customer service center of Guoneng Rixin, dedicated and caring.

Details of colorful Z590M motherboard (1);

The protagonist of this test is CVN Z590M GAMING FROZEN V20 from Colorful, which is an M-ATX architecture motherboard with Intel Z590 chipset. Different from CVN Z590M GAMING V20, the motherboard with the FROZEN logo adopts the main color of white, which is suitable for building a pure white computer host with various white computer accessories.

Although the positioning of the motherboard is low-end, focusing on the people-friendly price, it is still necessary to improve the material specifications as much as possible in the power supply system to ensure the stable operation of the processor and allow users to simply overclock.

The CPU external auxiliary power supply of the motherboard is a single 8Pin.

The motherboard adopts the power supply design of 5-phase times 10-phase +2-phase. The 5-phase power supply has reached the CPU core power supply design equivalent to 10-phase through the phase doubling chip, and the nuclear display is a separate two-phase. Unfortunately, the above logo is batch, so the specific specifications cannot be found.

The PWM power supply is RT3609BE, which is a dual-channel CPU PMW power supply controller of Ruiyu, and it can support 6-phase (CORE VR)+2-phase (AXG VR) power supply design at most.

The heat dissipation module of the motherboard power supply system is composed of two parts, one of which is connected with the I/O panel through screws, and the other is independent. The total weight of the two aluminum blocks is 240g g..

In terms of memory, the motherboard supports DDR4-4266MHz(OC) memory at maximum, and X.M.P supports DDR4-3733MHz at maximum. The maximum capacity of four memory slots is only 128GB for dual channels, and the maximum capacity of a single memory slot is 32GB.

Good morning! Watching the news "morning reading" is coming!
Monday, May 27th, 2024, April 20th of the lunar calendar.
ShanghaiCloudy to cloudy, sometimes with showers or thunderstorms, 19~24℃

§Attention today

75 years ago today, Shanghai was liberated.　

※　To commemorate the 75th anniversary of Shanghai’s liberation, yesterday morning, the "Theme Report on Celebrating the 75th Anniversary of Shanghai’s Liberation" was held in the auditorium of Shanghai University, under the guidance of the Propaganda Department of Shanghai Municipal Committee and the Shanghai Double Support Office, and co-sponsored by Shanghai Yongjunyoushu Foundation, Shanghai University and Jiefang Daily.

The report fully reviewed the whole process of the liberation of Shanghai, and many descendants of heroic martyrs who liberated Shanghai took the stage to share touching stories. Representatives of students from Shanghai University, families of military martyrs from Jing ‘an and Baoshan District, and social support units for supporting the army and their families attended the report meeting.

Everyone has said that today’s peaceful and happy life is hard-won. We should respect heroes, forge ahead, inherit the red gene and build a glorious city together.

The Shanghai campaign won a total military and political victory.

To understand the significance of the important historical event of Shanghai liberation 75 years ago, we must first understand what happened in that year.

At the report meeting, Zhang Yun, a professor at the School of Political Science of National Defense University and honorary president of the Shanghai Society for the History of the Communist Party of China, gave a keynote speech entitled "An Important Battle Related to China’s Historical Destiny-Celebrating the 75th Anniversary of the Victory of the Shanghai Campaign", giving a detailed introduction from three aspects: the basic concept of the Shanghai Campaign, the way to win the Shanghai Campaign and the significance of the victory of the Shanghai Campaign.

The Battle of Shanghai lasted for 16 days from May 12 to May 27, 1949. It was the last battle of the Battle of Crossing the River, also known as the last battle of the Battle of Beijing, Shanghai and Hangzhou. It is a large-scale urban battle in the strategic pursuit of the People’s Liberation War, and it is also an important battle related to the historical destiny of China.

"In this battle, the People’s Liberation Army seized a large number of weapons, equipment and military supplies, handed Shanghai into the hands of the people completely, won a total victory in military and political affairs, and created a miracle in the history of war." Zhang Yun believes that the main way for the People’s Liberation Army to win lies in four aspects: brilliant strategic guidance, orderly pre-war preparation, heroic urban attack and unique winning model.

Zhang Yun pointed out that the fate of Shanghai is actually a microcosm of the historical fate of modern China. Since modern times, the rise and fall of the Chinese nation, the safety of honor and disgrace have always been closely related to this city. The liberation of Shanghai is a change of the times and a turning point in history. In addition, the victory of the Shanghai campaign has profound and extensive contemporary significance, of which the most fundamental and crucial one is that those who win the hearts of the people win the world.

"In the new historical period, we must follow the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era,’ Jiangshan is the people and the people are the mountains’ and forge ahead on the journey of the great rejuvenation of the Chinese nation." Zhang Yun said.

The story of martyrs is touching.

The liberation of Shanghai was exchanged for the blood of revolutionary martyrs. During the 16-day battle, PLA soldiers braved the bullets and marched forward bravely, and more than 24,000 officers and men were gloriously injured, and 7,613 officers and men gave their lives. Three descendants of heroic martyrs were invited to the report, and they told touching stories of their ancestors who fought bloody battles and liberated Shanghai.

The 87th Division of 29 army, 10th Corps of the Third Field Army, fired the first shot of Shanghai’s liberation, and then attacked Yuepu Town from the western front. Zhang Qiangsheng son of the general Zhang Xiaoyu, commander of the 87th Division, recalled that May 14th was a crucial day for the battle order to capture Yuepu Town. Zhang Qiangsheng, deputy commander Lin Naiqing and chief of staff Ye Keshou went to the front positions respectively to learn about the situation and plan and organize the second storm. By dawn on the 15th, the 87th Division occupied Yuepu Town, realizing the strategic intention of the Central Committee.

In the fierce battle in Yuepu, Hu Wenjie, head of the 259th Regiment of the 87th Division, was unfortunately shot while commanding the battle and died heroically. He was the highest-ranking commander of our army who died in the battle of Shanghai. Twenty-two days after Hu Wenjie’s death, his youngest son, Hu Jijun, was born.

"Father’s combat is characterized by being forward and sinking. Before the war, he personally approached reconnaissance and reconnaissance of the terrain. He tried to observe and command as close as possible in the battle and adjusted in time according to changes in the enemy’s situation." Hu Jijun said that in the battle on May 14th, Hu Wenjie’s hand-held carbine personally led the troops to continue to attack the enemy positions, and finally opened a breakthrough to drive the enemy out of Yuepu. Later, he organized troops to build fortifications and deploy defenses overnight. "According to comrades’ memories, my father didn’t sleep for more than 70 hours in his life, and he spent it in fighting with the enemy and bullets."

From January to May, 1949, there were 100 local martyrs who died for the liberation of Shanghai, including 68 Communist party member and revolutionary volunteers. Chen Guanning’s parents, Chen Erjin and Wang Manxia, could have enjoyed a good life, but they resolutely joined the Communist Party of China (CPC) and risked their lives to lurk in the Kuomintang for more than ten years.

"Before the start of the Shanghai campaign, parents sent people to Danyang to report the uprising action plan. Unfortunately, the action plan was discovered by Kuomintang agents. On May 9, my parents were arrested, along with me, who was only 11 months old. " With the rescue of the Shanghai Party organization, the Kuomintang authorities were forced to release Chen Guanning. On May 19th, Chen Erjin and Wang Manxia went to the execution ground in Song Park (now Zhabei Park), when Wang Manxia was pregnant. Later, the Central People’s Government ratified Chen Erjin and Wang Manxia as revolutionary martyrs.

【Relive the red memory]

Today’s Liberation Daily 5th Edition > > >?Don’t forget to create difficulties.?

Today’s Liberation Daily 6 > > > How to win the battle of "military and political victory"

§Newspaper reading

SAIC’s "Seven Technical Bases" Jumped to the 2.0 Era　

"Strong Body", "Strong Heart" and "Intelligent Brain" —— Creating a brand-new "scientific and technological life"　

Today’s Liberation Daily 1st Edition > > >

Counting 100,000 books, this "person" completed it in one night.　

Sazhi Intelligent Zhang Jianzheng led the team to launch a variety of mobile robots one after another.　

Today’s Liberation Daily 2nd Edition > > >

§Shencheng

Food fume along Lingshi Road disturbs people, even if the license is complete, it will be rectified immediately.

Cooking fume disturbing people is one of the air pollution problems that people complain a lot and reflect strongly.

Details > > >

Interview with ERT team leader Xu Jiatai: "Win the world championship together!"

The team will make a major upgrade to the car next season.　

Details > > >

●Yesterday, 34.9℃ was the highest temperature in Shanghai this year.

Ida Plaza, a large domestic cruise ship "Ida Modu" filmed on May 26th. On May 26th, the reporter walked into the "Ada Modu", the first domestic large-scale cruise ship independently built and operated in China, and felt the charm of this "modern city at sea" from a distance.

§domestic

The Taiwan authorities instigated a very small number of countries to throw Taiwan-related proposals again, and the China delegation responded.

Inappropriate and impractical.　

Details > > >

In this "World Cup" in Dalian, China won both men’s and women’s football teams.

In the men’s final of the 2024 FIFA World Cup, the China team played against the Ugandan team.　

Details > > >

●"Excerpts from the Supreme Leader’s Discussion on Comprehensively Strengthening the Party’s Discipline Construction" was published.

●Jiangxi arranges 200 million yuan to promote home improvement and replacement of automobile appliances.

This is Xiong ‘an Shijia Hutong Primary School and Beijing No.4 Middle School Xiong ‘an Campus (photo taken on May 21, drone photo) located in the starting area of xiong’an new area. In recent years, xiong’an new area, Hebei Province has continuously promoted the high-quality development of education by innovating the system and mechanism of education development, setting up high-standard educational facilities, introducing professional teachers and introducing high-quality educational resources. At present, there are 717 schools in xiong’an new area with 235,000 students and 20,000 teachers.

§international

After more than four years, the China-Japan-ROK Leaders’ Meeting resumed: What are the highlights? What will it bring?

The three countries are willing and necessary to establish closer and more stable cooperative relations and work together to deal with various problems and challenges.　

Details > > >

●A fire at a baby care center in Delhi, India, killed seven babies.

●Israeli bombing of a refugee camp in Rafah killed at least 40 people.

●At least nine people were killed when a strong storm hit the central United States.

●An earthquake of magnitude 6.3 occurred in the waters off Vanuatu.

●Japanese researchers use stem cells to cultivate cells that can differentiate into sperm and eggs.

This is the area where the landslide occurred in Nga province, Papua New Guinea on May 24th. Serhan Aktoprak, head of the United Nations International Organization for Migration in Papua New Guinea, said that the death toll from the landslide in Papua New Guinea on the 24th may exceed 670, according to the Australian Broadcasting Corporation.

　　With the country’s emphasis on the well-being of people’s livelihood, the national subsidy policy in 2024 (referred to as "state subsidy") has once again become the focus of attention of consumers. This policy aims to reduce the economic burden of consumers when buying household appliances, mobile phones and other commodities through financial subsidies. So, how to receive state compensation? On which platform can the national supplement be received? The following is a detailed interpretation.

　　First, the conditions and scope of receiving state subsidies

　　First of all, it is necessary to clarify the scope and conditions of application of state compensation. In 2024, the state subsidy policy is mainly aimed at consumers who buy first-class energy efficiency/water efficiency and second-class energy efficiency/water efficiency products. The subsidy intensity is 20% and 15% respectively, and the maximum subsidy amount does not exceed 2,000 yuan.

　　There are a wide range of commodities participating in subsidies, including but not limited to large household appliances such as household appliances and mobile phones and 3C digital products. At present, the government’s household appliance subsidy policy has covered many areas including Zhejiang, Sichuan, Shandong, Jiangsu, Guizhou, Guangzhou and Shanghai.

　　Related reading: 2024 government home appliance subsidy projector inventory! Zhejiang/Guangdong/Fujian/Sichuan and many other places can get it.

　　Second, the platform and steps for receiving state subsidies

　　The collection platforms of state subsidies are mainly divided into life apps in JD.COM, China Unionpay Quick Pass, Tik Tok and China Construction Bank, as well as people’s livelihood apps belonging to various regions (such as "One Code Connect" in Guizhou). The collection steps of different platforms are slightly different, but the general process is similar. Detailed tutorials mainly focus on JD.COM and Tik Tok:

　　1. JD.COM Platform

　　JD.COM platform is one of the main channels for receiving state subsidies, and the specific steps are as follows:

　　Step one:Search for "State Subsidy 2024" on the homepage of JD.COM APP. If the subsidy has been opened in the region, there will be a quick access entrance. For example, if I want to buy a projector, I will directly search for the subsidy of "projector", and I will also jump to the national subsidy page. We can see that many provinces have participated in the subsidy at present.

　　Step two:Click on the collection entrance to enter the subsidy collection page. Select the province where you are located and check the categories of subsidies you can receive.

　　Step 3:Click "Receive Qualification" to complete the qualification collection; After receiving the voucher, it will be automatically deposited into JD.COM account. When purchasing goods that meet the subsidy conditions, you can enjoy the discount by choosing to pay with subsidy vouchers.

　　2. Tik Tok Platform

　　The specific steps are as follows:

　　Step one:Open Tik Tok APP and search the flagship store of the product you want to buy in the search box. For example, search for "official flagship store of Dangbei" and enter the store page, and you can see that some products are marked with the logo of [20% reduction for state subsidies] in the list of products for sale.

　　Step two:Select the goods that meet your needs from the list of goods and enter the payment page. Take the new "Dangbei F7 Pro" projector as an example, select the goods with the logo of [20% reduction for state subsidies], and after entering the payment page, you will see the prompt of "20% reduction for government subsidies at the maximum" in the "total concessions" section, and you need to complete real-name authentication at this time;

　　Step 3:After the real-name authentication is successful, click Buy Now, and the receiving address can be anywhere in the country (except Hong Kong, Macao and Taiwan), and you can enjoy the subsidy after payment. The original price of 7,999 yuan for the Dangbei F7 Pro projector was reduced by 1,115.85 yuan (15%), plus the 400 yuan coupon for the platform and the 160 yuan coupon for the store, only 6,323.15 yuan was needed!

　　3. China Unionpay Quick Pass Platform

　　The China Unionpay Quick Pass platform also supports the collection of state subsidies, but it should be noted that some areas may need to jump to China Unionpay Quick Pass to qualify first. The specific steps are as follows:

　　Step one:After obtaining the qualification in JD.COM or the designated platform, if you are prompted to jump to China Unionpay Quick Pass, download and register the China Unionpay Quick Pass APP.

　　Step two:In China Unionpay Quick Pass APP, find the "Home Appliances Subsidy" or "State Subsidy" area and enter the collection page.

　　Step 3:Select the region and subsidy category, and click "Eligibility".

　　Step 4:When purchasing goods, you can enjoy preferential subsidies by choosing China Unionpay Quick Pass as the payment method.

　　4. CCB Life APP Platform

　　CCB Life APP is also one of the platforms for receiving state subsidies, but attention should be paid to the list of enterprises and stores participating in the activities. The specific steps are as follows:

　　Step one:Download and register CCB Life APP.

　　Step two:Find the "national subsidy" or "home APPliance subsidy" activity entrance in the app.

　　Step 3:Select the region and subsidy category, and click "Eligibility".

　　Step 4:Go to the designated store to buy goods, use CCB Life APP to pay, and you can enjoy the subsidy discount.

　　Third, matters needing attention

　　1. Real name use:National supplement qualification can only be obtained once in each category, used once, and must be used in real name. Different regions and platforms cannot be collected and used repeatedly.

　　2. Timely use:After receiving the qualification, it should be used in time to avoid expiration. The validity period of subsidy vouchers in different regions may be different, and they need to be collected and used according to the rules of the region.

　　3. Platform selection:Before receiving the qualification, consumers should first check the platform selected by enterprises or stores in the list of participating enterprises and stores published by official website.

　　4. Payment method:Subsidy vouchers in some regions need to be paid on designated platforms, such as China Unionpay Quick Pass. When purchasing, make sure to choose the right payment method to enjoy the subsidy.

　　Four, the new area to receive the process:

　　The national subsidy policy in 2024 provided tangible benefits for consumers. By understanding and following the above collection steps and precautions, you can easily collect and use the national supplementary coupons and enjoy the benefits brought by shopping. At the same time, it is also recommended to pay attention to the latest news and activity rules released by the government to ensure that no preferential opportunities are missed. Take the Danube projector as an example,Nowadays, there is still the last month left in the 24-year subsidy, and the Double Twelfth and New Year Festival are just around the corner. The official subsidy price given by Dangbei is shown as follows, so buy early and enjoy early!

　　1. How to use the government subsidy for trade-in in Hubei? Hubei trade-in subsidy collection method

　　2.2024 How to get the old-for-new subsidy in Guangdong? Guangdong Trade-in Subsidy Collection Course

　　3. How does Zhejiang Province use home appliance subsidies to purchase projection? Tutorial for Replenishment of Dangbei Projection Country in 2024

　　4. How does Dangbei Projection in Sichuan Province receive the government renewal subsidy? Detailed course of actual measurement

　　5.2024 How to get the Jiangsu government’s home appliance subsidy? Detailed explanation of Jiangsu household appliance subsidy process

Omicron is the most serious mutation so far. There are more than 30 mutations in spike protein, 15 of which occur in receptor binding domain (RBD). This COVID-19 mutant poses new challenges to scientific research and epidemic prevention decision-making. A recent study published in Nature, a top academic journal, pointed out that a key question for China is whether the inactivated vaccine that has been inoculated on a large scale also has a severe protective effect on Omicron mutant.　

On January 28th, Nature published a study jointly completed by researchers from the Institute of Biophysics of Chinese Academy of Sciences, the Institute of Medical Experimental Animals of China Academy of Medical Sciences, the Institute of Microbiology and Epidemiology of the Academy of Military Medicine of the Academy of Military Sciences, China Institute of Food and Drug Control (NIFDC), Beijing Kexing Biological Products Co., Ltd., etc. The research team systematically analyzed the titer of neutralizing antibodies in the serum of volunteers vaccinated with CoronaVac and the antibody spectrum of memory B lymphocytes.　

The research was led by researcher Wang Xiangxi from Institute of Biophysics of Chinese Academy of Sciences and Key Laboratory of Infection and Immunity of Chinese Academy of Sciences. Other correspondents included researcher Qin Chengfeng from Institute of Microbiology and Epidemiology of Academy of Military Medicine of Chinese Academy of Military Sciences, Wang Youchun, chief expert of vaccine testing of China Food and Drug Testing Institute, and Qin Chuan, director of Institute of Medical Experimental Animals of China Academy of Medical Sciences.　

It is mentioned in the paper that although the currently approved COVID-19 vaccine continues to be effective against serious diseases and deaths caused by Delta mutants, the third dose of vaccine or even the development of new vaccine is needed due to the decreased immunity and large-scale breakthrough infection caused by virus mutation.

Previously, on December 8, 2021, Pfizer announced that a preliminary laboratory study showed that three doses of Pfizer /Biontech mRNA COVID-19 vaccine BNT162b2 could neutralize the mutant strain in Omicron, Covid-19. Compared with two doses of vaccine, inoculation of three doses of the vaccine increased the titer of neutralizing antibody by 25 times.

The research team believes that these preliminary data about Omicron neutralization sensitivity need further independent verification, and the clinical effects of natural immunity and vaccine-induced immunity in preventing infection and serious diseases also need urgent investigation. As far as China is concerned, inactivated vaccine has been inoculated on a large scale up to now. Does this also have a serious protective effect on Omicron mutant? What is the necessity of three doses of vaccination?

In this study, Wang Xiangxi et al. collected the sera of 60 volunteers who had been inoculated with inactivated vaccine twice (in the procedure of October and January) and 60 volunteers who had been inoculated with inactivated vaccine three times (in the procedure of October, January and July), and evaluated their neutralization titer against the original strain and Omicron mutant by COVID-19 live virus neutralization test. None of these volunteers were infected with Covid-19 before the study, and blood samples collected four weeks after the last vaccination were used in the study.

Evolution and neutralization characteristics of Omicron mutant.

The data showed that the geometric mean median maximum neutralization titer (GMT NT50) of the volunteers inoculated with three doses of inactivated COVID-19 vaccine against wild-type (WT) virus, Delta and Omicron mutant were 253.9, 77.8 and 15.4, respectively. Compared with the wild-type virus, the semi-maximum neutralization titer of Delta and Omicron decreased by 3.3 times and 16.5 times respectively. Three of the 60 volunteers had an NT50 titer of less than 8 for Omicron. In other words, the seroconversion rate of neutralizing antibody against Omicron in volunteers vaccinated with three doses of inactivated COVID-19 vaccine was 95%.

However, they mentioned in their research that what deserves more attention at present is the effectiveness of the two-dose vaccination program for Omicron infection. In the two-dose inoculation group, compared with the wild-type (WT) virus, the NT50 titer of Delta was 6.6, which was 5.1 times lower. Notably, none of the 60 volunteers had a serum sample with an NT50 titer greater than 8 for Omicron.

These results showed that the neutralizing ability of COVID-19 mutant strain was poor after inoculation with two doses of inactivated vaccine, and the neutralizing antibody titer in vivo could be improved by inoculation with the third dose of inactivated vaccine. However, the titer of neutralizing antibody against Omicron mutant was still low. The research team believes that their data is consistent with previous observations, that is, three doses of inactivated vaccine inoculation can enhance the neutralization breadth of SARS-CoV-2 mutant.

Strengthen the characteristics of broad-spectrum neutralizing antibodies in needle volunteers.

It is worth noting that after the existing vaccination, the level of neutralizing antibody in serum is not enough to fully curb breakthrough infection, so why can it effectively provide severe protection?

The research team isolated immunoglobulin (IgG+) memory B cells from peripheral blood mononuclear cells (PBMCs) of four three-dose vaccinators, obtained the sequences of antibody heavy chain and light chain variable regions and expressed 323 strains of antibodies in vitro. They found that 163 antibodies recognized virus RBD, 100 antibodies recognized NTD and 51 antibodies recognized S2. The test results also showed that almost all antibodies that bind to RBD can bind to wild-type strains, among which 127 antibodies have neutralizing activity against wild-type strains of real and pseudoviruses, and they chose these antibodies for further study.

Among these 127 strains of antibodies, more than 93% showed extensive binding activity to most of the mutants of concern and interest. It is worth noting that 85% of these antibodies cross-react with Omicron RBD.

In contrast, about 80% of NTD-binding antibodies lost their cross-reaction with Omicron. In addition, due to the great diversity of NTD, the cross-reaction of NTD antibody to the other four variants of concern is relatively poor.

Their research also found that among the antibodies binding to RBD region, 31 strains can effectively neutralize wild-type pseudoviruses and true viruses and all concerned variants, and the semi-inhibitory concentration IC50 is between 0.002 and 0.800μg/ml. Among them, 30 strains of antibodies can directly block the binding between RBD and ACE2.

Among the 31 strains of broad-spectrum potent antibodies isolated in this study, 13 strains have IC50 less than 0.02ug/ml to Omicron, which is 10-40 times as high as that of VIR-7831 from GSK/Vir and DXP-604 which is still in the clinical trial stage in China.

The structural basis of extensive and effective neutralization of representative antibodies.

The research team also selected four antibodies for further structural biological analysis. Among them, XGV347 (class II antibody) and XGV289 (class IV antibody) have strong neutralizing activity against all concerned mutants, including Omicron.

They also identified the interaction between these antibodies and Omicron spike protein, and identified a mutation G446S of spike protein, which is more resistant to a class of antibodies that bind to the receptor binding domain and is a key escape site.

Structural comparison shows that XGv347 is similar to a neutralizing antibody (A23-58.1) which is effective against several Covid-19 mutants, and is similar to the epitope (antibody binding site) targeted by another neutralizing antibody (S2K146). It is worth noting that S2K146 is effective against other strains of coronavirus B (i.e., subgenus sarbecovirus, a group of virus strains to which Covid-19 belongs).

Further experiments in this study also show that the representative broad-spectrum neutralizing antibody therapy has a high protective effect on the infection of beta mutant and Omicron mutant in mice.

Protective effect of neutralizing antibody therapy on infection of beta mutant and Omicron mutant in mice.

The research team believes that this study proves that the three-dose vaccination program is reasonable under the current pandemic. At the same time, antibodies that identify and identify epitopes in the same region can be classified, and different types of antibodies can form cocktail therapy, which can be used to prevent and treat current epidemic strains and new strains that may appear in the future, or help to develop a general vaccine strategy for branch B of coronavirus B.

Original link: https://www.nature.com/articles/s41586-022-04466-x